Not necessarily. Certain investment-in-process and escrow arrangements can support a filing before a transaction fully closes, so the sequencing should follow a review of the specific proposed terms rather than a general assumption that closing must come first.
Coordinate the transaction timeline with the immigration process
Identify who can adjust closing and release conditions if the immigration review takes longer than expected, and confirm the applicable consular or status procedure for the specific applicant. Keep a target opening date separate from the government's own processing timeline, and revisit the plan if ownership or financing terms change.
Canadian citizens generally need an E visa rather than seeking admission without one, so build in application preparation and an interview step when setting milestones for the opening. Set milestones: amended terms signed, payment released from escrow, delivery schedule confirmed, evidence pack reviewed. Sequence the source-of-funds trail, due diligence, negotiated contingencies, binding commitments, visa application, travel, and business opening. Canadian citizens apply for an E-2 visa at a consulate, so plan the closing sequence around that process, and remember that E-2 provides no direct path to permanent residence.